Humans, apes, and guinea pigs cannot generally synthesize Vitamin C. In contrast, most all other mammals have the capability to synthesize C. Horses have that capability, too. Even so, it is little appreciated among horsemen that the rigorous training regimes of racehorses along with the stress of all types of opportunistic infections can increase a horse's need for far more Vitamin C than he can synthesize. It seems quite likely to me that the pulmonary bleeding seen in many racehorses may be a manifestation of not only a lung biofilm infection, but secondarily, a vitamin C deficiency caused by such an infection. This is the Ahart Hypothesis which can be read else where in this site. Note that scurvy in humans, a disease of Vitamin C deficiency, is characterized by easy hemorrhage of the tissues. It is often thought that many disease syndromes can produce a sub-clinical case of scurvy. Mega-doses of intravenous Vitamin C may be a valuable therapy for the racing and bleeding horse. It would not only help battle the infection, but guard against hemorrhage. Animals in the wild are generally suggested to be of much healthier stock than our livestock in captivity and part of this may point to the fact that wild animals tend to have such higher capabilities of synthesizing Vitamin C plus live under less stress and capable of obtaining higher Vitamin C foods in the wild. What this all may mean is that simple oral dosing of Vitamin C supplements may not be enough even for those animals that can make their own! The exception might be oral liposomal encapsulated (LET) Vitamin C, but I will not go into this here. This technology is described on another webpage of this site. Generally, when an organism is diseased and in demand of large quantities of Vitamin C, one must pulse high quantities of Vitamin C directly into the blood stream to produce high blood concentrations which can reach the needy tissues. This is why intravenous (i.v.) administration of Vitamin C is the only alternative to effectively treating of many diseases, excepting LET protocols.
Frederick Robert Klenner, M.D. was the main inspiration for mega-dosage Vitamin C therapy as I describe it here. He was a practicing physician in North Carolina in the 1940s and 50s. He was the inspiration for the work done by Linus Pauling who is better known as the Champion of Vitamin C. Few have heard of Klenner. Dr. Levy points out in his book, Curing the Incurable , that Klenner: "…always based subsequent dosing on the degree of general clinical response and the extent of which an elevated temperature had been lowered from the previous vitamin C dose." This may exactly be another reason why modern physicians tend to ignore Vitamin C. They do not want the intensive protocol of continually monitoring the patient for future adjustments in C dosage. This is very much like how herbs should be prescribed and why herbs lost popularity for the modern synthetic medicines. The dose's response dictates the next dosage level. Not a good paradigm for a factory, cookie-cutter medical practice! Some viral infections can easily burn up 300-400 grams of Vitamin C daily. One must give that much to stay even with the fight for health! Levy writes: "The rule of thumb in vitamin C treatment of viral diseases is to continue increasing the dose as long as the clinical response is inadequate or unsatisfactory and to continue the treatment period until all clinical symptoms have disappeared."
Klenner presented over 20 papers outlining his life's work with Vitamin C. In 1949, he cured 60 out of 60 polio cases. It was probably Claus Washington Jungeblut, M.D. that first give Klenner the idea to employ Vitamin C for polio though he may deny it. Jungeblut published in 1935, his idea that ascorbic acid, Vitamin C, could inactivate bacterial and viral pathogens along with their toxins. Some of his earliest work was with bacterial toxins, such as tetanus, diphtheria, and staph toxins which he found could be inactivated by Vitamin C along with the polio, hepatitis and herpes viruses. Irwine Stone, the biochemist writes: "Within two years after the discovery of ascorbic acid, Jungeblut showed that ascorbic acid would inactivate the virus of poliomyelitis. This was followed, in 1936-1937, in rapid succession by other workers showing similar inactivation of other viruses: by Holden et al., using the herpes virus; by Kligler and Bernkopf, on the vaccina virus, by Lagenbusch and Enderling, with the virus of hoof-and-mouth disease; by Amato, on the rabies virus; by Lominski, using bacteriophage; and by Lojkin and Martin, with the tobacco mosaic disease virus. Thus, at this early date it was established that ascorbic acid had the potential of being a wide-spectrum antiviral agent."
After Jungeblut's well known notoriety in the 1930s and 40s in Polio research, he seemed to disappear into anonymity along with all the research of Vitamin C as an antimicrobial. This was mainly due to the efforts of the famous, Dr. Albert B. Sabin. Dr. Sabin was the champion at this time in live polio virus vaccine research. He attempted to repeat Jungeblut's groundbreaking work showing that polio infected monkeys benefited by Vitamin C administration. Sabin could not reproduce Jungeblut's success which was later evaluated by Jungeblut, himself, as Sabin using far too low of dosages on monkeys, who were far sicker than his in the lab trials. Sabin gave one single small dose of 400 mg to only one animal and for only one day. Imagine giving a similar dosage of one of our current antibiotics and hoping for a cure? Impossible. Sabin's resulting negative published results effectively stifled all future work with Vitamin C in the context as an anti-viral compound. Sabin went on to perfect a live virus vaccine, but in the meantime, he came into conflict with Dr. Salk who worked at vaccinating polio from the dead virus perspective. As with Jungeblut's Vitamin C research, Sabin did everything in his power to condemn the work of Salk. He was quoted of being very bombastic and intolerant of new ideas. Here we see how medical history is such a fickle maiden. Salk would mostly have been stopped in his tracks from further work on a dead virus vaccine had it not been for Basil O'Connor, an appointee by Franklin D. Roosevelt. O'Connor was in charge of the goverment grant purse strings in stimulating polio research. Salk and O'Connor met by happenstance and O'Connor was impressed with this young researcher, Jonas Salk! He believed in Salk's work and was a nonfliching supporter of Salk and powerful enough to defy Sabin. In the end. Salk was allowed to complete his successful polio dead virus vaccine merely because he had friends in high places who never stopped funneling money to his lab! Just imagine what might have happened if O'Connor had met and liked Dr. Jungeblut or Dr. Klenner!
Dr.Klenner in the late 1940s took Jungeblut's work a bit further by administering 20-40 grams of Vitamin C per day with stunning results. Andrew W. Saul writes: "Curiously, the only report on vitamin C and polio that Klenner had at that time read was Sabin's negative one. Klenner writes that his own "observations of the action of ascorbic acid on virus diseases were made independently of any knowledge of previous studies using vitamin C on virus pathology, except for the negative report of Sabin after treating Rhesus monkeys experimentally infected with the poliomyelitis virus." Then he reviewed the literature, finding: ". . .an almost unbelievable record of such studies. The years of labor in animal experimentation, the cost in human effort and in grants, and the volumes written, make it difficult to understand how so many investigators could have failed in comprehending the one thing that would have given positive results a decade ago. This one thing was the size of the dose of vitamin C employed and the frequency of its administration. In all fairness it must be said that Jungeblut noted on several occasions that he attributed his failure of results to the possibility that the strength of his injectable 'C' was inadequate. It was he who unequivocally said that ''vitamin C can truthfully be designated as the antitoxic and antiviral vitamin.'" And so went Dr. Klenner groundbreaking work, who inspired a few other renegades such as Dr. Robert Cathcart, Dr. W. Bellfield, Thomas Levy, but few others.
Dr.Klenner's life work with intravenous Vitamin C involved treating a number of different syndromes with success beyond his Polio experiences. He found that Virus Pneumonia, Hepatitis, Herpes Simplex & Zoster, Chicken Pox, measles, mumps, Mononucleosis, diphtheria, Rocky Mountain Spotted Fever, Cardiovascular diseases, hypermenorrhea, peptic and duodenal ulcers, postoperative and radiation sickness, rheumatic fever, scarlet fever, acute and chronic pancreatitis, tularemia, whooping cough, Tetanus (Lockjaw)., Urethritis, Chronic cystitis, and tuberculosis all responded well. He found that many heavy metal and toxins could be removed or neutralized by Vitamin C. He treated many toxic animal bites with Vitamin C.
The sad facts are since Linus Pauling's later widely read work on the wonders of Vitamin C resulted in such controversy, the medical establishment has stubbornly closed ranks in their consensus of the minimal value of Vitamin C in medical pathology come hell or high water. They seemed to have deemed it a closed case with little more to be learned from this substance. You can see this strong entrenched bias even to today.
I would like to champion the use of Ascorbic Acid (VItamin C) for the use on racehorses. It is one therapy little used and which can offer much benefit in fighting obscure diseases in hopeless patients. It could be particularly valuable for the bleeding racehorse.